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Open Access Article

International Journal of Brain Research. 2022; 2: (1) ; 1-4 ; DOI: 10.12208/j.ijbs.20220001.

Clinical effect of paliperidone in the treatment of schizophrenia
帕利哌酮治疗精神分裂症患者的临床效果

作者: 卜琴芳*,

中国人民解放军第九〇四医院常州医疗区 江苏常州

*通讯作者: 卜琴芳,单位:中国人民解放军第九〇四医院常州医疗区 江苏常州;

发布时间: 2022-09-06 总浏览量: 36

摘要

目的 分析帕利哌酮用于精神分裂症的价值。方法 对2020年6月-2022年5月本院接诊精神分裂症病人(n=82)进行随机分组,试验和对照组各41人,前者用帕利哌酮,后者用奥氮平。对比不良反应等指标。结果 关于不良反应,试验组的发生率2.44%,和对照组9.76%相比无显著差异(P>0.05)。关于总有效率,试验组的数据95.12%,和对照组80.49%相比更高(P<0.05)。关于PANSS评分,疗程结束之时:试验组的数据(45.16±4.28)分,和对照组(67.93±6.41)分相比更低(P<0.05)。关于PSP评分,疗程结束之时:试验组的数据(86.21±2.57)分,和对照组(76.47±4.13)分相比更高(P<0.05)。关于用药满意度,试验组的数据97.56%,和对照组78.05%相比更高(P<0.05)。结论 精神分裂症用帕利哌酮,不良反应更少,疗效更为显著,精神症状缓解也更为迅速,社会功能改善更加明显,用药满意度更高。

关键词: 精神分裂症;不良反应;帕利哌酮;价值

Abstract

Objective To analyze the value of paliperidone in schizophrenia.
Methods A total of 82 schizophrenic patients (n=82) admitted to our hospital from June 2020 to May 2022 were randomly divided into experimental group and control group, with 41 patients in each group. The former were treated with paliperidone, and the latter with olanzapine. Adverse reactions and other indicators were compared.
Results The incidence of adverse reactions in the experimental group was 2.44%, which was not significantly different from 9.76% in the control group (P>0.05). The total effective rate of the experimental group was 95.12%, which was higher than that of the control group (80.49%, P<0.05). At the end of the course of treatment, the PANSS score of the experimental group (45.16±4.28) was lower than that of the control group (67.93±6.41) (P<0.05). Regarding PSP score, at the end of the course of treatment, the data of the experimental group (86.21±2.57) was higher than that of the control group (76.47±4.13) (P<0.05). The satisfaction rate of the experimental group was 97.56%, which was higher than that of the control group (78.05%, P<0.05).
Conclusion   The use of paliperidone in schizophrenia has less adverse reactions, more significant curative effect, more rapid relief of mental symptoms, more obvious improvement of social function, and higher drug satisfaction.

Key words: Schizophrenia; Adverse reactions; Paliperidone; Value

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引用本文

卜琴芳, 帕利哌酮治疗精神分裂症患者的临床效果[J]. 国际脑科学研究, 2022; 2: (1) : 1-4.