Clinical study of clopidogrel combined with prostaglandin in the treatmentof cerebral infarction caused by middle cerebral artery stenosis
氯吡格雷联合前列地尔治疗大脑中动脉狭窄致脑梗死的临床研究

摘要

目的 探讨在大脑中动脉狭窄致脑梗死治疗中应用氯呲格雷联合前列地尔的效用价值。方法 此次实验共选取106例患者进行对比实验，因研究需对结果展开深入对比，以此来判别不同治疗方案的可行性，所以还需做好分组工作，采取摇号方式随机将其分为对照组与观察两个组别，均为53例患者，前者行氯呲格雷治疗，后者在此基础上联合前列地尔治疗，对两组实际应用效果进行评价。结果 经研究数据表明，在治疗前两组患者炎性指标水平、血流动力学、NIHSS、ADL等指标水平相对较为均衡（P＞0.05）；但实施不同治疗方案后，观察组患者Hs-CRP、TNF-α、IL-6以及血浆黏度、血浆纤维蛋白原、血小板聚集率均低于对照组，与此同时相比对照组，观察组患者NIHSS评分降低，ADL评分大幅度提升（P＜0.05）。结论 在大脑中动脉狭窄导致的脑梗死患者展开治疗时应用氯呲格雷与前列地尔联合用药方式可有效降低患者炎性指标水平，改善其血流动力学，减轻神经功能缺损程度，促进患者日常生活能力的提升。

Abstract

Objective To investigate the utility value of clopidogrel combined with prostaglandin in the treatment of cerebral infarction caused by middle cerebral artery stenosis.
Methods A total of 106 patients were selected for the comparison experiment, because the study needs to carry out an in-depth comparison of the results, so as to judge the feasibility of different treatment plans, so it is also necessary to do a good job of grouping, taking the shaking of the number of the way randomly divided into the control group and the observation of the two groups, both of them are 53 cases of patients, the former line of chorizopride treatment, the latter on the basis of the combination of prostaglandin treatment, the actual application of the effect of the two groups was evaluated. Evaluation of the actual application effect of the two groups.
Results The study data showed that before treatment, the levels of inflammatory indexes, hemodynamics, NIHSS, ADL and other indexes of the two groups were relatively balanced (P＞0.05); however, after the implementation of different treatment plans, Hs-CRP, TNF-α, IL-6, plasma viscosity, plasma fibrinogen, platelet aggregation rate of the observation group were lower than that of the control group, and at the same time, compared to the control group, the NIHSS of the patients of the observation group was lower than that of the control group. control group, NIHSS scores of patients in the observation group were reduced and ADL scores were substantially improved (P < 0.05).
Conclusion   In the treatment of patients with cerebral infarction caused by middle cerebral artery stenosis, the combination of clonidine and prostaglandin can effectively reduce the level of inflammatory indexes, improve the hemodynamics, reduce the degree of neurological deficits, and promote the enhancement of patients' daily life ability.