Effectiveness of simvastatin combined with aspirin in the treatment of cerebral thrombosis and the effecton neurological deficits
辛伐他汀联合阿司匹林治疗脑血栓的效果及对神经功能缺损的影响

摘要

目的 分析研究对脑血栓患者实施辛伐他汀联合阿司匹林治疗的效果以及对神经功能缺损的影响。方法 选取82例经颅脑CT确诊为脑血栓的患者作为研究对象，同时将患者分配为使用不同治疗方法的对照组、观察组，并分别对其实施阿司匹林治疗、阿司匹林联合辛伐他汀治疗，比较治疗效果。结果 首先评估了两组患者的神经功能缺损和日常生活能力改善情况，结果显示，实施阿司匹林联合辛伐他汀治疗的观察组，治疗后其神经功能缺损和日常生活能力改善情况更优（P＜0.05）；其次，从临床疗效角度分析看，观察组、对照组的治疗总有效率分别为95.12%、85.92%，观察组疗效更高（P＜0.05）；而且经颈动脉超声检查分析看，治疗后观察组患者颈动脉中层内膜厚度、斑块面积均低于对照组（P＜0.05）。结论 对脑血栓患者实施辛伐他汀与阿司匹林联合治疗能够减轻神经功能缺损、改善日常生活能力，同时可减少颈动脉斑块的厚度及面积，对提升患者预后情况有积极意义。

Abstract

Objective To analyze and study the effect of simvastatin combined with aspirin treatment on patients with cerebral thrombosis and the effect on neurological deficits.
Methods Eighty-two patients diagnosed as cerebral thrombosis by cranial brain CT were selected as the study subjects, and the patients were also allocated into the control group and the observation group using different treatments, and aspirin treatment and aspirin combined with simvastatin treatment were implemented to them respectively to compare the treatment effects.
Results Firstly, the improvement of neurological deficits and daily living ability of the two groups was assessed, and the results showed that the improvement of neurological deficits and daily living ability of the observation group treated with aspirin combined with simvastatin was better after treatment (P＜0.05); secondly, from the perspective of clinical efficacy, the total efficacy rate of the observation group and the control group was 95.12%, 85.92%, the observation group has higher efficacy (P < 0.05); and the carotid ultrasonography analysis shows that the carotid artery middle layer intima-media thickness and plaque area of the patients in the observation group are lower than those in the control group after treatment (P < 0.05).
Conclusion   The combination of simvastatin and aspirin in patients with cerebral thrombosis can reduce neurological deficits, improve the ability of daily life, and at the same time reduce the thickness and area of carotid plaque, which is of positive significance in improving the prognosis of patients.